Background: Drug-drug interplay (DDI) is a critical public well being challenge. The L1000 database of the LINCS undertaking has collected hundreds of thousands of genome-wide expressions induced by 20,000 small molecular compounds on 72 cell traces. Whether or not this unified and complete transcriptome information useful resource can be utilized to construct a greater DDI prediction mannequin continues to be unclear. Due to this fact, we developed and validated a novel deep studying mannequin for predicting DDI utilizing 89,970 recognized DDIs extracted from the DrugBank database (model 5.1.4).
Outcomes: The proposed mannequin consists of a graph convolutional autoencoder community (GCAN) for embedding drug-induced transcriptome information from the L1000 database of the LINCS undertaking; and an extended short-term reminiscence (LSTM) for DDI prediction. Comparative analysis of varied machine studying strategies demonstrated the superior efficiency of our proposed mannequin for DDI prediction. Lots of our predicted DDIs have been revealed within the newest DrugBank database (model 5.1.7). Within the case research, we predicted medication interacting with sulfonylureas to trigger hypoglycemia and medicines interacting with metformin to trigger lactic acidosis, and confirmed each to induce results on the proteins concerned within the metabolic mechanism in vivo.
Conclusions: The proposed deep studying mannequin can speed up the invention of recent DDIs. It could actually help future medical analysis for safer and simpler drug co-prescription.

Genorise® Semen DNA Extraction Kit 500 |
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GR101041 | Genorise Scientific | 500 | EUR 480 |
Genorise® Semen DNA Extraction Kit 200 |
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GR101042 | Genorise Scientific | 200 | EUR 258 |
Genorise® Semen DNA Extraction Kit 100 |
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GR101043 | Genorise Scientific | 100 | EUR 144 |
Genorise® Semen DNA Extraction Kit 50 |
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GR101044 | Genorise Scientific | 50 | EUR 87 |
Genorise® Semen Stain DNA Extraction Kit 1000 |
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GR101017 | Genorise Scientific | 1000 | EUR 1045 |
Genorise® Semen Stain DNA Extraction Kit 500 |
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GR101069 | Genorise Scientific | 500 | EUR 564 |
Genorise® Semen Stain DNA Extraction Kit 200 |
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GR101070 | Genorise Scientific | 200 | EUR 243 |
Genorise® Semen Stain DNA Extraction Kit 100 |
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GR101071 | Genorise Scientific | 100 | EUR 144 |
Genorise® Semen Stain DNA Extraction Kit 50 |
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GR101072 | Genorise Scientific | 50 | EUR 87 |
AI-91K LN2 Freezer for Bulk Semen Storage, no controller |
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TW-AI-91K | MiTeGen | 1 UNIT | EUR 66671 |
Description: AI-91K LN2 Freezer for Bulk Semen Storage, no controller |
Semenogelin I Protein |
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20-abx261182 | Abbexa |
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Semenogelin I antibody |
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70R-1587 | Fitzgerald | 100 ug | EUR 452.4 |
Description: Rabbit polyclonal Semenogelin I antibody raised against the N terminal of SEMG1 |
Semenogelin I antibody |
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70R-1593 | Fitzgerald | 100 ug | EUR 452.4 |
Description: Rabbit polyclonal Semenogelin I antibody raised against the C terminal of SEMG1 |
Semenogelin I antibody |
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70R-5491 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Rabbit polyclonal Semenogelin I antibody raised against the middle region of SEMG1 |
Semenogelin I (SEMG1) Antibody |
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abx237711-100ug | Abbexa | 100 ug | EUR 661.2 |
Semenogelin I (SEMG1) Antibody |
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20-abx174508 | Abbexa |
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Semenogelin I (SEMG1) Antibody |
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20-abx322135 | Abbexa |
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Semenogelin I (SEMG1) Antibody |
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20-abx115422 | Abbexa |
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Semenogelin I (SEMG1) Antibody |
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abx028130-400ul | Abbexa | 400 ul | EUR 627.6 |
Semenogelin I (SEMG1) Antibody |
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abx028130-80l | Abbexa | 80 µl | EUR 343.2 |
Semenogelin I (SEMG1) Antibody |
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20-abx129235 | Abbexa |
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Semenogelin I (SEMG1) Antibody |
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20-abx320262 | Abbexa |
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Semenogelin I (SEMG1) Antibody |
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20-abx004204 | Abbexa |
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Recombinant Semenogelin I (SEMG1) |
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4-RPH185Hu01 | Cloud-Clone |
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Description: Recombinant Human Semenogelin I expressed in: E.coli |
Semenogelin I Blocking Peptide |
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33R-7601 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEMG1 antibody, catalog no. 70R-1587 |
Semenogelin I Blocking Peptide |
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33R-3239 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEMG1 antibody, catalog no. 70R-1593 |
Semenogelin I Blocking Peptide |
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33R-4289 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEMG1 antibody, catalog no. 70R-5491 |
Human Semenogelin I (SEMG1) Protein |
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20-abx168081 | Abbexa |
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Human Semenogelin I (SEMG1) CLIA Kit |
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20-abx495402 | Abbexa |
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Lung Diabetic Disease Lysate |
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XBL-10362 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human lung tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human lung tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the lung tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The lung tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Human Semenogelin I (SEMG1) ELISA Kit |
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abx250766-96tests | Abbexa | 96 tests | EUR 904.8 |
Human Semenogelin I (SEMG1) ELISA Kit |
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abx571776-96tests | Abbexa | 96 tests | EUR 904.8 |
Human Semenogelin I (SEMG1) ELISA Kit |
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DLR-SEMG1-Hu-48T | DL Develop | 48T | EUR 620.4 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Semenogelin I (SEMG1) in samples from serum, plasma, seminal plasma or other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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DLR-SEMG1-Hu-96T | DL Develop | 96T | EUR 807.6 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Semenogelin I (SEMG1) in samples from serum, plasma, seminal plasma or other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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20-abx153055 | Abbexa |
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Human Semenogelin I (SEMG1) ELISA Kit |
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RDR-SEMG1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 652.8 |
Human Semenogelin I (SEMG1) ELISA Kit |
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RDR-SEMG1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 907.2 |
Human Semenogelin I (SEMG1) ELISA Kit |
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RD-SEMG1-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 625.2 |
Human Semenogelin I (SEMG1) ELISA Kit |
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RD-SEMG1-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 867.6 |
Human Semenogelin I(SEMG1)ELISA Kit |
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QY-E01566 | Qayee Biotechnology | 96T | EUR 448.8 |
Human Semenogelin I (SEMG1) ELISA Kit |
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SEH185Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5677.8 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Semenogelin I (SEMG1) in serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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SEH185Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 572.76 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Semenogelin I (SEMG1) in serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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SEH185Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 766.8 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Semenogelin I (SEMG1) in serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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SEH185Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3090.6 |
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Semenogelin I (SEMG1) in serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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4-SEH185Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Semenogelin I (SEMG1) in samples from serum, plasma, seminal plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
Human Semenogelin I (SEMG1) ELISA Kit |
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RDR-SEMG1-Hu-48T | Reddot Biotech | 48T | EUR 475.34 |
Description: serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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RDR-SEMG1-Hu-96T | Reddot Biotech | 96T | EUR 679.04 |
Description: serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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RD-SEMG1-Hu-48T | Reddot Biotech | 48T | EUR 452.7 |
Description: serum, plasma, seminal plasma and other biological fluids. |
Human Semenogelin I (SEMG1) ELISA Kit |
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RD-SEMG1-Hu-96T | Reddot Biotech | 96T | EUR 646.7 |
Description: serum, plasma, seminal plasma and other biological fluids. |
Total RNA - Diabetic Disease: Colon |
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R1236090Dia-50 | Biochain | 50 ug | EUR 421.2 |
Colon Diabetic Disease Lysate |
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XBL-10333 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human colon tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human colon tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the colon tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The colon tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Ileum Diabetic Disease Lysate |
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XBL-10379 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human small intestine: Ileum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human small intestine: Ileum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the small intestine: Ileum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The small intestine: Ileum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Total RNA - Diabetic Disease: Stomach |
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R1236248Dia-50 | Biochain | 50 ug | EUR 421.2 |
Jejunum Diabetic Disease Lysate |
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XBL-10381 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human small intestine: Jejunum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human small intestine: Jejunum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the small intestine: Jejunum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The small intestine: Jejunum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Stomach Diabetic Disease Lysate |
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XBL-10387 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human stomach tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human stomach tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the stomach tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The stomach tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Total RNA - Diabetic Disease: Pancreas |
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R1236188Dia-50 | Biochain | 50 ug | EUR 421.2 |
Duodenum Diabetic Disease Lysate |
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XBL-10336 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human duodenum tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human duodenum tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the duodenum tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The duodenum tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
ELISA kit for Human SEMG1 (Semenogelin I) |
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ELK4641 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
Description: A sandwich ELISA kit for detection of Semenogelin I from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Total RNA - Diabetic Disease: Esophagus |
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R1236106Dia-50 | Biochain | 50 ug | EUR 421.2 |
Esophagus Diabetic Disease Lysate |
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XBL-10338 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human esophagus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human esophagus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the esophagus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The esophagus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Pancrease Diabetic Disease Lysate |
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XBL-10371 | ProSci | 0.1 mg | EUR 796.2 |
Description: Human pancrease tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human pancrease tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the pancrease tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The pancrease tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
cDNA - Human Diabetic Diseased Tissue: Lung |
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C1236152Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Skin |
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C1236218Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Brain |
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C1236035Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Colon |
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C1236090Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Heart |
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C1236122Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Liver |
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C1236149Dia | Biochain | 40 reactions | EUR 729 |
SEMG1 Semenogelin I Human Recombinant Protein |
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PROTP04279 | BosterBio | Regular: 20ug | EUR 380.4 |
Description: SEMG1 Human Recombinant produced in E. coli is a single polypeptide chain containing 462 amino acids (24-462) and having a molecular mass of 52kDa. SEMG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
Semenogelin I (SEMG1) Polyclonal Antibody (Human) |
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4-PAH185Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1) |
cDNA - Human Diabetic Diseased Tissue: Whole Eye |
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C1236108Dia-10 | Biochain | 10 reactions | EUR 393 |
cDNA - Human Diabetic Diseased Tissue: Kidney |
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C1236142Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Spleen |
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C1236246Dia | Biochain | 40 reactions | EUR 729 |
Skeletal Muscle Diabetic Disease Lysate |
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XBL-10369 | ProSci | 0.1 mg | EUR 796.2 |
Description: human skeletal muscle tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human skeletal muscle tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the Skeletal Muscle tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The Skeletal Muscle tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Collagen Type I (Collagen Type I) Antibody |
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abx231836-100ug | Abbexa | 100 ug | EUR 610.8 |
Collagen Type I (Collagen Type I) Antibody |
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abx020882-100ug | Abbexa | 100 ug | EUR 1161.6 |
Collagen Type I (Collagen Type I) Antibody |
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abx022733-05ml | Abbexa | 0.5 ml | EUR 1713.6 |
Collagen Type I (Collagen Type I) Antibody |
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abx022734-02mg | Abbexa | 0.2 mg | EUR 1312.8 |
Collagen Type I (Collagen Type I) Antibody |
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abx022736-05ml | Abbexa | 0.5 ml | EUR 1696.8 |
Collagen Type I (Collagen Type I) Antibody |
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abx022737-05ml | Abbexa | 0.5 ml | EUR 1412.4 |
Collagen Type I (Collagen Type I) Antibody |
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20-abx101265 | Abbexa |
|
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Collagen Type I (Collagen Type I) Antibody |
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20-abx101266 | Abbexa |
|
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Collagen Type I (Collagen Type I) Antibody |
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20-abx130515 | Abbexa |
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cDNA - Human Diabetic Diseased Tissue: Lymph Node |
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C1236161Dia-10 | Biochain | 10 reactions | EUR 393 |
cDNA - Human Diabetic Diseased Tissue: Stomach |
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C1236248Dia | Biochain | 40 reactions | EUR 729 |
cDNA - Human Diabetic Diseased Tissue: Bone Marrow |
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C1236024Dia-10 | Biochain | 10 reactions | EUR 420 |
cDNA - Human Diabetic Diseased Tissue: Pancreas |
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C1236188Dia | Biochain | 40 reactions | EUR 729 |
Pancreas Membrane Diabetic Disease Lysate |
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XBL-10785 | ProSci | 0.1 mg | EUR 752.1 |
Description: Human pancreas tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human pancreas tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated pancreas tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated pancreas tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal. |
cDNA - Human Diabetic Diseased Tissue: Esophagus |
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C1236106Dia | Biochain | 40 reactions | EUR 729 |
Membrane Protein - Diabetic Disease: Pancreas |
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P3236188Dia | Biochain | 0.1 mg | EUR 410 |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), PE |
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4-PAH185Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with PE. |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), APC |
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4-PAH185Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with APC. |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), Cy3 |
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4-PAH185Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with Cy3. |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), HRP |
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4-PAH185Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with HRP. |
Total Protein - Human Diabetic Diseased Tissue: Lung |
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P1236152Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Skin |
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P1236218Dia | Biochain | 1 mg | EUR 471 |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), FITC |
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4-PAH185Hu01-FITC | Cloud-Clone |
|
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with FITC. |
Adipose Subcutaneous Diabetic Disease Lysate |
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20-105 | ProSci | 0.1 mg | EUR 1508.1 |
Description: Human subcutaneous adipose tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human subcutaneous adipose tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the subcutaneous adipose tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The subcutaneous adipose tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Total Protein - Human Diabetic Diseased Tissue: Brain |
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P1236035Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Colon |
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P1236090Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Heart |
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P1236122Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Liver |
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P1236149Dia | Biochain | 1 mg | EUR 471 |
cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle |
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C1236171Dia | Biochain | 40 reactions | EUR 729 |
Total Protein - Human Diabetic Diseased Tissue: Whole Eye |
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P1236108Dia | Biochain | 1 mg | EUR 1147 |
Total Protein - Human Diabetic Diseased Tissue: Kidney |
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P1236142Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Spleen |
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P1236246Dia | Biochain | 1 mg | EUR 471 |
Skeletal Muscle Membrane Diabetic Disease Lysate |
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XBL-10855 | ProSci | 0.1 mg | EUR 752.1 |
Description: human skeletal muscle tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human skeletal muscle tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated Skeletal Muscle tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated Skeletal Muscle tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal. |
cDNA - Human Diabetic Diseased Tissue: Visceral Adipose |
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C1236003VisDia-10 | Biochain | 10 reactions | EUR 420 |
Membrane Protein - Diabetic Disease: Skeletal Muscle |
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P3236171Dia | Biochain | 0.1 mg | EUR 410 |
Total Protein - Human Diabetic Diseased Tissue: Adrenal |
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P1236004Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Stomach |
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P1236248Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Bone Marrow |
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P1236024Dia | Biochain | 1 mg | EUR 1147 |
Total Protein - Human Diabetic Diseased Tissue: Pancreas |
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P1236188Dia | Biochain | 1 mg | EUR 471 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Eye |
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T1236108Dia | Biochain | 5 slides | EUR 662 |
cDNA - Human Diabetic Diseased Tissue: Small Intestine: Ileum |
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C1236227Dia | Biochain | 40 reactions | EUR 729 |
Total Protein - Human Diabetic Diseased Tissue: Esophagus |
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P1236106Dia | Biochain | 1 mg | EUR 471 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Lung |
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T1236152Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin |
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T1236218Dia | Biochain | 5 slides | EUR 475 |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), APC-Cy7 |
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4-PAH185Hu01-APC-Cy7 | Cloud-Clone |
|
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with APC-Cy7. |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Brain |
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T1236035Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon |
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T1236090Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Heart |
|||
T1236122Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Liver |
|||
T1236149Dia | Biochain | 5 slides | EUR 475 |
Semenogelin I (SEMG1) Polyclonal Antibody (Human), Biotinylated |
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4-PAH185Hu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Semenogelin I (SEMG1). This antibody is labeled with Biotin. |
cDNA - Human Diabetic Diseased Tissue: Subcutaneous Adipose |
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C1236003SubDia-10 | Biochain | 10 reactions | EUR 420 |
cDNA - Human Diabetic Diseased Tissue: Small Intestine: Jejunum |
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C1236230Dia | Biochain | 40 reactions | EUR 729 |
Genomic DNA - Human Diabetic Diseased Tissue: Lung, from a single donor |
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D1236152Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Skin, from a single donor |
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D1236218Dia | Biochain | 50 ug | EUR 489 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Kidney |
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T1236142Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Spleen |
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T1236246Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung |
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T2236152Dia | Biochain | 5 slides | EUR 238 |
cDNA - Human Diabetic Diseased Tissue: Small Intestine: Duodenum |
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C1236101Dia | Biochain | 40 reactions | EUR 729 |
Genomic DNA - Human Diabetic Diseased Tissue: Colon, from a single donor |
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D1236090Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Heart, from a single donor |
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D1236122Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Liver, from a single donor |
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D1236149Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Brain, from a single donor |
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D1236035Dia | Biochain | 50 ug | EUR 489 |
Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle |
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P1236171Dia | Biochain | 1 mg | EUR 471 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Adrenal |
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T1236004Dia | Biochain | 5 slides | EUR 475 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Stomach |
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T1236248Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon |
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T2236090Dia | Biochain | 5 slides | EUR 238 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver |
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T2236149Dia | Biochain | 5 slides | EUR 238 |
Genomic DNA - Human Diabetic Diseased Tissue: Whole Eye, from a single donor |
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D1236108Dia | Biochain | 50 ug | EUR 1152 |
Genomic DNA - Human Diabetic Diseased Tissue: Kidney, from a single donor |
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D1236142Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Spleen, from a single donor |
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D1236246Dia | Biochain | 50 ug | EUR 489 |
Total Protein - Human Diabetic Diseased Tissue: Visceral Adipose |
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P1236003VisDia | Biochain | 1 mg | EUR 1147 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow |
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T1236024Dia | Biochain | 5 slides | EUR 662 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Pancreas |
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T1236188Dia | Biochain | 5 slides | EUR 475 |
Genomic DNA - Human Diabetic Diseased Tissue: Stomach, from a single donor |
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D1236248Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Adrenal, from a single donor |
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D1236004Dia | Biochain | 50 ug | EUR 489 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Esophagus |
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T1236106Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Stomach |
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T2236248Dia | Biochain | 5 slides | EUR 238 |
Genomic DNA - Human Diabetic Diseased Tissue: Esophagus, from a single donor |
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D1236106Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Pancreas, from a single donor |
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D1236188Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Bone Marrow, from a single donor |
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D1236024Dia | Biochain | 50 ug | EUR 1152 |
Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Ileum |
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P1236227Dia | Biochain | 1 mg | EUR 471 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow |
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T2236024Dia | Biochain | 5 slides | EUR 238 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Esophagus |
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T2236106Dia | Biochain | 5 slides | EUR 238 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Pancreas |
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T2236188Dia | Biochain | 5 slides | EUR 238 |
Total Protein - Human Diabetic Diseased Tissue: Subcutaneous Adipose |
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P1236003SubDia | Biochain | 1 mg | EUR 1147 |
Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Duodenum |
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P1236101Dia | Biochain | 1 mg | EUR 471 |
Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Jejunum |
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P1236230Dia | Biochain | 1 mg | EUR 471 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Visceral Adipose |
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T1236003VisDia | Biochain | 5 slides | EUR 662 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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T1236171Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid |
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T2236189Dia | Biochain | 5 slides | EUR 629 |
Genomic DNA - Human Diabetic Diseased Tissue: Skeletal Muscle, from a single donor |
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D1236171Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Visceral Adipose, from a single donor |
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D1236003VisDia | Biochain | 50 ug | EUR 1152 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum |
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T1236227Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle |
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T2236171Dia | Biochain | 5 slides | EUR 238 |
Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Ileum, from a single donor |
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D1236227Dia | Biochain | 50 ug | EUR 489 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Subcutaneous Adipose |
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T1236003SubDia | Biochain | 5 slides | EUR 662 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum |
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T1236230Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum |
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T2236227Dia | Biochain | 5 slides | EUR 238 |
Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Jejunum, from a single donor |
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D1236230Dia | Biochain | 50 ug | EUR 489 |
Genomic DNA - Human Diabetic Diseased Tissue: Subcutaneous Adipose, from a single donor |
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D1236003SubDia | Biochain | 50 ug | EUR 1152 |
Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum |
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T1236101Dia | Biochain | 5 slides | EUR 475 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum |
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T2236230Dia | Biochain | 5 slides | EUR 238 |
Procollagen Type I (212-216) |
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H-1592.0005 | Bachem | 5.0mg | EUR 151.2 |
Description: Sum Formula: C23H45N7O9; CAS# [149128-48-3] |
Procollagen Type I (212-216) |
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H-1592.0025 | Bachem | 25.0mg | EUR 501.6 |
Description: Sum Formula: C23H45N7O9; CAS# [149128-48-3] |
Collagen Type I protein |
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30R-AC016 | Fitzgerald | 500 ug | EUR 528 |
Description: Purified native Human Collagen Type I Solution |
Collagen Type I protein |
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E62L001 | EnoGene | 1mg | EUR 1425.6 |
Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Duodenum, from a single donor |
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D1236101Dia | Biochain | 50 ug | EUR 489 |
Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum |
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T2236101Dia | Biochain | 5 slides | EUR 238 |
Collagen Type I antibody |
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10-1800 | Fitzgerald | 200 ul | EUR 846 |
Description: Mouse monoclonal Collagen Type I antibody |
Collagen Type I antibody |
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10R-C139b | Fitzgerald | 100 ug | EUR 976.8 |
Description: Mouse monoclonal Collagen Type I antibody |
Collagen Type I antibody |
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20R-CR025 | Fitzgerald | 500 ul | EUR 950.4 |
Description: Rabbit polyclonal Collagen Type I antibody |
Collagen Type I antibody |
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70R-CR007x | Fitzgerald | 100 µg | EUR 379.2 |
Description: Affinity purified Rabbit polyclonal Collagen Type I antibody |
Collagen Type I antibody |
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PAab09910 | Lifescience Market | 100 ug | EUR 463.2 |
Procollagen Type I protein |
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E62L008 | EnoGene | 100ug | EUR 1035.6 |
Type I Safety Can 4L |
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SAF7976 | Scientific Laboratory Supplies | EACH | EUR 143.62 |
Background: Diabetes and consuming problems are steadily comorbid. This explicit comorbidity just isn’t solely usually poorly recognised, however is tough to deal with and has a excessive mortality.
Methodology: On this article, we’ll briefly evaluation the connection between diabetes and consuming problems. We are going to evaluation the present NICE and different steering and studies regarding each diabetes and consuming problems in the UK. We are going to then describe the suggestions of the 2018 Welsh Authorities Consuming Dysfunction Service Evaluate and the 2021 the Scottish Authorities Consuming Dysfunction Service Evaluate concerning diabetes and consuming problems, which is able to result in service change.
Conclusions: We conclude that this can be a comparatively underdeveloped however necessary space the place there must be additional service improvement and extra collaboration between diabetes and consuming dysfunction providers.
Introduction: Sodium-glucose co-transporter-2 (SGLT2) inhibitors reasonably scale back glucose ranges in type-2 diabetes mellitus (T2DM). Some instances of diabetic ketoacidosis (DKA) have been reported with SGLT2 inhibitors. Nevertheless, information on the long-term security of dapagliflozin in Saudi Arabia are missing. The current research aimed to watch the protection of dapagliflozin in sufferers with T2DM and consider the change in HbA1c through the remark interval in comparison with baseline.
Strategies: This was an area, potential, single-arm, non-interventional, regulatory post-marketing research. The research was performed in Saudi Arabia from Might 2017 to September 2019. Sufferers acquired both 5 or 10 mg dapagliflozin together with weight loss program and train modifications to deal with T2DM. The incidence of antagonistic occasions was noticed over the therapy period and for Three days after administering the final dose of dapagliflozin.
Outcomes: A complete of 527 sufferers have been recruited within the research, 524 of which have been eligible for the statistical evaluation. About 62% have been males. The median (IQR) age was 52.3 (14.8) years, whereas the median (IQR) physique mass index was 31.6 (7.7) kg/m2. The median (IQR) period because the sufferers have been first identified with T2DM was 8.78 (6.73) years. The commonest comorbidities have been hyperlipidemia (51.1%) and hypertension (41.1%). Virtually three-quarters of the research inhabitants (73.7%) acquired different antidiabetic drugs along with dapagliflozin.
Over a interval of 12 months, a complete of 106 antagonistic occasions have been skilled by 65 (12.33%) sufferers. Vulvovaginal pruritus (3.1%), dysuria (2.7%), polyuria (1.3%), urinary tract infections (1%), fatigue (0.8%), and hypoglycemia (0.8%) have been among the many reported antagonistic occasions. One case of DKA (0.2%) was reported. The imply (SD) HbA1c% degree considerably decreased from 8.6 (1.6) % at baseline to succeed in 7.2 (1.2) % after 12 months of therapy (p < 0.0001).
Conclusion: Dapagliflozin was discovered to be a effectively tolerated and efficient therapy possibility for T2DM sufferers in Saudi Arabia. Vulvovaginal pruritus and dysuria have been the commonest antagonistic occasions.
Goals: To judge the long-term penalties of espresso ingesting in sufferers with kind 2 diabetes.
Information synthesis: PubMed, Scopus, and Net of Sciences have been searched to November 2020 for potential cohort research evaluating the affiliation of espresso ingesting with danger of heart problems (CVD) and mortality in sufferers with kind 2 diabetes. Two reviewers extracted information and rated the certainty of proof utilizing GRADE method. Random-effects fashions have been used to estimate the hazard ratios (HRs) and 95% CIs. Dose-response associations have been modeled by a one-stage mixed-effects meta-analysis. Ten potential cohort research with 82,270 instances have been included. In comparison with these with no espresso consumption,
the HRs for consumption of Four cups/d have been 0.79 (95%CI: 0.72, 0.87; n = 10 research) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n = 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n = 3) for coronary coronary heart illness (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n = 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n = 2) for whole CVD occasions. There was no vital affiliation for most cancers mortality and stroke. There was an inverse monotonic affiliation between espresso ingesting and all-cause and CVD mortality, and inverse linear affiliation for CHD and whole CVD occasions. The understanding of proof was graded average for all-cause mortality, and low or very low for different outcomes.
Conclusions: Consuming espresso could also be inversely related to the danger of mortality in sufferers with kind 2 diabetes. Nevertheless, extra analysis is required contemplating kind of espresso, sugar and cream added to espresso, and historical past of CVD to current extra assured outcomes.