Novel deep learning-based transcriptome data analysis

Novel deep learning-based transcriptome data analysis

Background: Drug-drug interplay (DDI) is a critical public well being challenge. The L1000 database of the LINCS undertaking has collected hundreds of thousands of genome-wide expressions induced by 20,000 small molecular compounds on 72 cell traces. Whether or not this unified and complete transcriptome information useful resource can be utilized to construct a greater DDI prediction mannequin continues to be unclear. Due to this fact, we developed and validated a novel deep studying mannequin for predicting DDI utilizing 89,970 recognized DDIs extracted from the DrugBank database (model 5.1.4).
Outcomes: The proposed mannequin consists of a graph convolutional autoencoder community (GCAN) for embedding drug-induced transcriptome information from the L1000 database of the LINCS undertaking; and an extended short-term reminiscence (LSTM) for DDI prediction. Comparative analysis of varied machine studying strategies demonstrated the superior efficiency of our proposed mannequin for DDI prediction. Lots of our predicted DDIs have been revealed within the newest DrugBank database (model 5.1.7). Within the case research, we predicted medication interacting with sulfonylureas to trigger hypoglycemia and medicines interacting with metformin to trigger lactic acidosis, and confirmed each to induce results on the proteins concerned within the metabolic mechanism in vivo.
Conclusions: The proposed deep studying mannequin can speed up the invention of recent DDIs. It could actually help future medical analysis for safer and simpler drug co-prescription.
phrconference
phrconference

Type I Diabetes Serum, Human Donor

MBS170481-1Sample 1Sample
EUR 310

Type I Diabetes Serum, Human Donor

MBS170481-5Samples 5Samples
EUR 960

Type I Diabetes Serum, Human Donor

MBS170481-5x5Samples 5x5Samples
EUR 4110

Plasma - Type I Diabetes - Patient Sample

MBS170490-1Sample 1Sample
EUR 310

Plasma - Type I Diabetes - Patient Sample

MBS170490-5Samples 5Samples
EUR 1005

Plasma - Type I Diabetes - Patient Sample

MBS170490-5x5Samples 5x5Samples
EUR 4310

Human Muscle Myoblasts, Diabetes Type I

ABC-TC3956 1 vial Ask for price
Description: Diabetic Type I and Type II HSMM-Human Skeletal Muscle Myoblasts are isolated from donors diagnosed with either Diabetes Type I or Diabetes Type II. Additional donor information is available by contacting Scientific Support.

Single Donor Human Type I Diabetes Urine

IRHUURESDIBTI250ML each
EUR 1063
Description: Single Donor Human Type I Diabetes Urine

Single Donor Human Type I Diabetes Urine

IRHUURESDIBTI50ML each
EUR 439
Description: Single Donor Human Type I Diabetes Urine

Single Donor Human Type I Diabetes Urine

MBS8421330-250mL 250mL
EUR 1285

Single Donor Human Type I Diabetes Urine

MBS8421330-50mL 50mL
EUR 595

Single Donor Human Type I Diabetes Urine

MBS8421330-5x250mL 5x250mL
EUR 5540

Whole Blood - Type I Diabetes - Patient Sample

MBS170486-1Sample 1Sample
EUR 310

Whole Blood - Type I Diabetes - Patient Sample

MBS170486-5x1Sample 5x1Sample
EUR 4310

Preadipocytes, visc 1M cells, Diabetes Type I

LOPT-5023 each
EUR 1155.54

Preadipocytes, subcu 1M cells, Diabetes Type I

LOPT-5021 each
EUR 782.64

Diabetes (Type 1) Exosome

P141-DB1 - Ask for price

Diabetes (Type 2) Exosome

P141-DB2 - Ask for price

Human Type 2 Diabetes PB

ABC-TC4312 1 pack Ask for price
Description: Non-RI dependent diabetes, or Type 2 Diabetes, is characterized by hyperglycemia that is caused by a combination of RI resistance and the body's inability to compensate by producing more RI.

Human Type 1 Diabetes Leukopak

ABC-TC4310 1 pack Ask for price
Description: RI dependent diabetes, or Type 1 Diabetes is caused by the pancreas producing little to no RI.

Human Type 2 Diabetes Leukopak

ABC-TC4311 1 pack Ask for price
Description: Non-RI dependent diabetes, or Type 2 Diabetes, is characterized by hyperglycemia that is caused by a combination of RI resistance and the body's s inability to compensate by producing more RI.

Human Type I Diabetes Peripheral Blood Mononuclear Cells

ABC-TC4263 1 vial Ask for price
Description: Peripheral blood mononuclear cells are isolated from Type I Diabetes peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Diabetic Type I PBMCs is available upon request.

Diabetes (Type 1) Exosome RNA

P241-DB1 - Ask for price

Diabetes (Type 2) Exosome RNA

P241-DB2 - Ask for price

D-Adipose-Derived stem cells, human, Type I Diabetes

LOPT-5007 each
EUR 748.19

Human Type II Diabetes PB Plasma

ABC-TC4266 1 vial Ask for price
Description: Type II Diabetes peripheral blood plasma is obtained by centrifugation of the Type II Diabetes PB. This product has a diminished number of cells and platelets. Fresh Diabetic Type II PB plasma is available upon request.

Type II Diabetes Serum, Human Donor

MBS170482-1Sample 1Sample
EUR 310

Type II Diabetes Serum, Human Donor

MBS170482-5Samples 5Samples
EUR 960

Type II Diabetes Serum, Human Donor

MBS170482-5x5Samples 5x5Samples
EUR 4110

Plasma - Type II Diabetes - Human Patient

MBS170491-1Sample 1Sample
EUR 310

Plasma - Type II Diabetes - Human Patient

MBS170491-5Samples 5Samples
EUR 1005

Plasma - Type II Diabetes - Human Patient

MBS170491-5x5Samples 5x5Samples
EUR 4310

Human iPS Cell Line (Type 2 Diabetes)

CSC-00849L One Frozen vial Ask for price

D-HAEC – Diseased Human Aortic Endothelial – Diabetes Type I

LOCC-2919 each
EUR 1920.94

Single Donor Human Type II Diabetes Urine

IRHUURESDIBTII250ML each
EUR 1063
Description: Single Donor Human Type II Diabetes Urine

Single Donor Human Type II Diabetes Urine

IRHUURESDIBTII50ML each
EUR 439
Description: Single Donor Human Type II Diabetes Urine

Single Donor Human Type II Diabetes Urine

MBS8421331-250mL 250mL
EUR 1285

Single Donor Human Type II Diabetes Urine

MBS8421331-50mL 50mL
EUR 595

Single Donor Human Type II Diabetes Urine

MBS8421331-5x250mL 5x250mL
EUR 5540

Human Muscle Myoblasts, Diabetes Type II

ABC-TC3957 1 vial Ask for price
Description: Diabetic Type I and Type II HSMM-Human Skeletal Muscle Myoblasts are isolated from donors diagnosed with either Diabetes Type I or Diabetes Type II. Additional donor information is available by contacting Scientific Support.

Whole Blood - Type II Diabetes - Patient Sample

MBS170487-1Sample 1Sample
EUR 310

Whole Blood - Type II Diabetes - Patient Sample

MBS170487-5x1Sample 5x1Sample
EUR 4310

D-AoSMC (Diseased Human Aortic Smooth Muscle), Diabetes Type I

LOCC-2914 each
EUR 1888.07

HighQC™ Human IPS Cell (Type 2 Diabetes)

ABC-SC0005T 1 vial Ask for price
Description: Induced Pluriopotent Stem Cells (iPSCs) are a type of pluripotent stem cells that can be derived directly from adult somatic cells . The derived iPSCs can propagate indefinitely, as well as give rise to other cell types in the body. iPS cells, thus, hold great promise in the field of regenerative medicine by representing a single source of cells that could be used to replace those damaged/diseased cells.

Preadipocytes, visc 1M cells, Diabetes Type II

LOPT-5024 each
EUR 1155.54

Preadipocytes, subcu 1M cells, Diabetes Type II

LOPT-5022 each
EUR 782.64

D-CASMC – Diseased Human Coronary Artery Smooth Muscle – Diabetes Type I

LOCC-2917 each
EUR 1880.03

D-HMVEC – Diseased Cardiac Microvascular Endothelial Cells – Diabetes Type I

LOCC-2927 each
EUR 1299.42

D-HCAEC – Diseased Human Coronary Artery Endothelial Cells – Diabetes Type I

LOCC-2921 each
EUR 1884.64

D-HPAEC – Diseased Human Pulmonary Artery Endothelial Cells – Diabetes Type I

LOCC-2923 each
EUR 1920.94

Human Type II Diabetes Peripheral Blood Mononuclear Cells

ABC-TC4265 1 vial Ask for price
Description: Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. A peripheral blood mononuclear cell is defined as any blood cell with a round nucleus. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of CD4+ and CD8+ T cells, B cells and Natural Killer cells, CD14+ Monocytes, and Basophils/Neutrophils/Eosinophils/Dendritic cells. These cells are often extracted from whole blood or from leukopacks using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma.Samples from each donor are tested via PCR to confirm non-reactivity. Peripheral blood mononuclear cells are isolated from Type II Diabetes peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Diabetic Type II PBMCs is available upon request.

D-Adipose-Derived stem cells, human, Type II Diabetes

LOPT-5008 each
EUR 748.19

D-PASMC (Diseased Human Pulmonary Artery Smooth Muscle Cells), Diabetes Type I

LOCC-2915 each Ask for price

D-HMVEC – Diseased Human Dermal Microvascular Endothelial Cells – Diabetes Type I

LOCC-2929 each
EUR 1169.49

D-HAEC – Diseased Human Aortic Endothelial – Diabetes Type II

LOCC-2920 each
EUR 1920.94

HighQC™ Human IPS Cell (Episomal/ Diabetes Type II/ Adipose)

ABC-SC0011T 1 vial Ask for price
Description: Gentaur offers human iPS cell lines derived from PBMCs, dermal fibroblasts, or adipose tissue of patients with Parkinson's Disease (PD) and Diabetes II. These iPS cells are established from a single clone and expanded in feeder-free conditions.

D-AoSMC (Diseased Human Aortic Smooth Muscle), Diabetes Type II

LOCC-2916 each Ask for price

HighQC™ Human IPS Cell (IPSC From PBMC/ Diabetes Type II/ Episomal)

ABC-SC0009T 1 vial Ask for price
Description: Gentaur offers human iPS cell lines derived from PBMCs, dermal fibroblasts, or adipose tissue of patients with Parkinson's Disease (PD) and Diabetes II. These iPS cells are established from a single clone and expanded in feeder-free conditions.

D-HCAEC – Diseased Human Coronary Artery Endothelial – Diabetes Type II

LOCC-2922 each
EUR 1884.64

D-CASMC – Diseased Human Coronary Artery Smooth Muscle – Diabetes Type II

LOCC-2918 each
EUR 1880.03

HighQC™ Human IPS Cell (IPSC From Fibroblast/ Diabetes Type II/ Episomal)

ABC-SC0010T 1 vial Ask for price
Description: Gentaur is is proud to offer human iPS cell lines derived from the human dermal fibroblasts from patients with Type 2 Diabetes (T2D). The pertinent donor information is available upon request. These iPS cells are established from a single clone and expanded in feeder-free conditions. Normal human iPS cell lines are also available as separate products . We also provide custom iPSC generation and iPSC differentiation services to meet your needs.

D-HMVEC – Diseased Cardiac Microvascular Endothelial Cells – Diabetes Type II

LOCC-2928 each Ask for price

D-HEK-Ad – Diseased Human Adult Epidermal Keratinocytes – Diabetes Type II

LOCC-2926 each
EUR 841.52

D-HPAEC – Diseased Human Pulmonary Artery Endothelial Cells – Diabetes Type II

LOCC-2924 each Ask for price

HighQC™ Human Bone Marrow Derived Mesenchymal Stem Cell/ Type II Diabetes Patient

ABC-SC0027T 1 vial Ask for price
Description: Human MSCs (Bone Marrow Derived) from a single adult donor clinically diagnosed with Type II Diabetes. The MSCs are compatible with our MSC Expansion Medium for Bone Marrow Derived MSCs.All of the cells provided are tested and are negative for HIV-1, HIV-2, Hepatitis B and Hepatitis C as detected by PCR. The cells are confirmed to be negative for mycoplasma and other detectable microbial contamination.

D-PASMC (Diseased Human Pulmonary Artery Smooth Muscle Cells), Diabetes Type II

LOCC-2913 each
EUR 1935.75

D-HMVEC – Diseased Human Dermal Microvascular Endothelial Cells – Diabetes Type II

LOCC-2930 each Ask for price

D-RPTEC – Diseased Human Renal Proximal Tubule Epithelial Cells – Diabetes Type II

LOCC-2925 each
EUR 2091.71

Linearity FD Special Diabetes

K889M-5 5 x 2 mL
EUR 374

Human Diabetes Lung Tissue Lysate

IHULGDIBTL100UG each
EUR 1413
Description: Human Diabetes Lung Tissue Lysate

Single Donor Human Diabetes Serum

ISERSDIB each
EUR 209
Description: Single Donor Human Diabetes Serum

Single Donor Human Diabetes Serum

MBS8421607-INQUIRE INQUIRE Ask for price

Human Diabetes Lung Tissue Lysate

MBS8414460-01mg 0.1mg
EUR 1810

Human Diabetes Lung Tissue Lysate

MBS8414460-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Colon Tissue Lysate

IHUCLNDIBTL100UG each
EUR 1413
Description: Human Diabetes Colon Tissue Lysate

Human Diabetes Ileum Tissue Lysate

IHUILMDIBTL100UG each
EUR 1413
Description: Human Diabetes Ileum Tissue Lysate

Single Donor Human Diabetes Plasma

IPLASDIB each
EUR 209
Description: Single Donor Human Diabetes Plasma

Single Donor Human Diabetes Plasma

MBS8421060-INQUIRE INQUIRE Ask for price

Human Diabetes Ileum Tissue Lysate

MBS8413586-01mg 0.1mg
EUR 1810

Human Diabetes Ileum Tissue Lysate

MBS8413586-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Colon Tissue Lysate

MBS139594-01mg 0.1mg
EUR 1810

Human Diabetes Colon Tissue Lysate

MBS139594-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Jejunum Tissue Lysate

IHUJEJDIBTL100UG each
EUR 1413
Description: Human Diabetes Jejunum Tissue Lysate

Human Diabetes Stomach Tissue Lysate

IHUSTDIBTL100UG each
EUR 1413
Description: Human Diabetes Stomach Tissue Lysate

Human Diabetes Jejunum Tissue Lysate

MBS8413808-01mg 0.1mg
EUR 1810

Human Diabetes Jejunum Tissue Lysate

MBS8413808-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Stomach Tissue Lysate

MBS8420033-01mg 0.1mg
EUR 1810

Human Diabetes Stomach Tissue Lysate

MBS8420033-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Duodenum Tissue Lysate

IHUDUODIBTL100UG each
EUR 1413
Description: Human Diabetes Duodenum Tissue Lysate

Human Diabetes Pancreas Tissue Lysate

IHUPCSDIBTL100UG each
EUR 1413
Description: Human Diabetes Pancreas Tissue Lysate

Human Diabetes Pancreas Tissue Lysate

MBS8416917-01mg 0.1mg
EUR 1810

Human Diabetes Pancreas Tissue Lysate

MBS8416917-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Duodenum Tissue Lysate

MBS8410767-01mg 0.1mg
EUR 1810

Human Diabetes Duodenum Tissue Lysate

MBS8410767-5x01mg 5x0.1mg
EUR 7965

Human Diabetes Esophagus Tissue Lysate

IHUESOPDIBTL100UG each
EUR 1413
Description: Human Diabetes Esophagus Tissue Lysate

Human Diabetes Esophagus Tissue Lysate

MBS8411234-01mg 0.1mg
EUR 1810

Human Diabetes Esophagus Tissue Lysate

MBS8411234-5x01mg 5x0.1mg
EUR 7965

Human Diabetes AdiposeVisceral Tissue Lysate

IHUADPTVDIBTL100UG each
EUR 2663
Description: Human Diabetes AdiposeVisceral Tissue Lysate

Human Diabetes AdiposeVisceral Tissue Lysate

MBS136954-01mg 0.1mg
EUR 3320

Human Diabetes AdiposeVisceral Tissue Lysate

MBS136954-5x01mg 5x0.1mg
EUR 14765

Human Diabetes Skeletal Muscle Tissue Lysate

IHUSKMDIBTL100UG each
EUR 1413
Description: Human Diabetes Skeletal Muscle Tissue Lysate

Human Diabetes Skeletal Muscle Tissue Lysate

MBS8419496-01mg 0.1mg
EUR 1810

Human Diabetes Skeletal Muscle Tissue Lysate

MBS8419496-5x01mg 5x0.1mg
EUR 7965

Human Diabetes AdiposeSubcutaneous Tissue Lysate

IHUADPTSDIBTL100UG each
EUR 2663
Description: Human Diabetes AdiposeSubcutaneous Tissue Lysate

Human Diabetes AdiposeSubcutaneous Tissue Lysate

MBS136950-01mg 0.1mg
EUR 3320

Human Diabetes AdiposeSubcutaneous Tissue Lysate

MBS136950-5x01mg 5x0.1mg
EUR 14765

Diabetes Drug Leads Bioactive Peptide Library

L-012 160 peptides
EUR 7938

Human Diabetes Pancreas Lysate Membrane Fraction

IHUPCSDIBTLM100UG each
EUR 1199
Description: Human Diabetes Pancreas Lysate Membrane Fraction

Human Diabetes Pancreas Lysate Membrane Fraction

MBS8416918-01mg 0.1mg
EUR 1550

Human Diabetes Pancreas Lysate Membrane Fraction

MBS8416918-5x01mg 5x0.1mg
EUR 6780

Linearity FLQ Special Diabetes for Roche Systems

K929M-5 5 x 2 mL
EUR 374

Tissue, Section, Human Disease, Diabetes, Eye (Frozen)

MBS640656-5Slides 5Slides
EUR 930

Tissue, Section, Human Disease, Diabetes, Eye (Frozen)

MBS640656-5x5Slides 5x5Slides
EUR 3955

Tissue, Total Protein, Human Disease, Diabetes, Lung

MBS657041-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Lung

MBS657041-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Skin

MBS657133-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Skin

MBS657133-5x1mg 5x1mg
EUR 3470

Linearity FLQ Special Diabetes for Abbott Systems

K956M-5 5 x 2 mL
EUR 374

Tissue, Section, Human Disease, Diabetes, Skin (Frozen)

MBS640139-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Skin (Frozen)

MBS640139-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Lung (Frozen)

MBS640535-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Lung (Frozen)

MBS640535-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Diabetes, Brain

MBS657014-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Brain

MBS657014-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Liver

MBS657060-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Liver

MBS657060-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Colon

MBS657406-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Colon

MBS657406-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Heart

MBS657486-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Heart

MBS657486-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Diabetes, Heart (Frozen)

MBS640578-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Heart (Frozen)

MBS640578-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Colon (Frozen)

MBS640835-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Colon (Frozen)

MBS640835-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Brain (Frozen)

MBS640760-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Brain (Frozen)

MBS640760-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Liver (Frozen)

MBS640704-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Liver (Frozen)

MBS640704-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Diabetes, Spleen

MBS657230-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Spleen

MBS657230-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Kidney

MBS657520-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Kidney

MBS657520-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Diabetes, Lung (Paraffin)

MBS640452-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Lung (Paraffin)

MBS640452-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Diabetes, Kidney (Frozen)

MBS639978-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Kidney (Frozen)

MBS639978-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Spleen (Frozen)

MBS640944-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Spleen (Frozen)

MBS640944-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Diabetes, Adrenal

MBS657074-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Adrenal

MBS657074-5x1mg 5x1mg
EUR 3470

Tissue, Total Protein, Human Disease, Diabetes, Stomach

MBS657368-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Stomach

MBS657368-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Diabetes, Colon (Paraffin)

MBS640373-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Colon (Paraffin)

MBS640373-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Diabetes, Adrenal (Frozen)

MBS640239-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Adrenal (Frozen)

MBS640239-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Stomach (Frozen)

MBS640568-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Stomach (Frozen)

MBS640568-5x5Slides 5x5Slides
EUR 3170

Tissue, Section, Human Disease, Diabetes, Liver (Paraffin)

MBS640786-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Liver (Paraffin)

MBS640786-5x5Slides 5x5Slides
EUR 2145

Tissue, Total Protein, Human Disease, Diabetes, Pancreas

MBS657129-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Pancreas

MBS657129-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Diabetes, Pancreas (Frozen)

MBS640252-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Pancreas (Frozen)

MBS640252-5x5Slides 5x5Slides
EUR 3170

Tissue, Total Protein, Human Disease, Diabetes, Esophagus

MBS657305-1mg 1mg
EUR 820

Tissue, Total Protein, Human Disease, Diabetes, Esophagus

MBS657305-5x1mg 5x1mg
EUR 3470

Tissue, Section, Human Disease, Diabetes, Stomach (Paraffin)

MBS640658-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Stomach (Paraffin)

MBS640658-5x5Slides 5x5Slides
EUR 2145

Tissue, Section, Human Disease, Diabetes, Esophagus (Frozen)

MBS640725-5Slides 5Slides
EUR 755

Tissue, Section, Human Disease, Diabetes, Esophagus (Frozen)

MBS640725-5x5Slides 5x5Slides
EUR 3170

Human Diabetes Skeletal Muscle Lysate Membrane Fraction

IHUSKMDIBTLM100UG each
EUR 1199
Description: Human Diabetes Skeletal Muscle Lysate Membrane Fraction

Tissue, Section, Human Disease, Diabetes, Pancreas (Paraffin)

MBS639953-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Pancreas (Paraffin)

MBS639953-5x5Slides 5x5Slides
EUR 2145

Tissue, Membrane Protein, Human Disease, Diabetes, Pancreas

MBS639798-01mg 0.1mg
EUR 695

Tissue, Membrane Protein, Human Disease, Diabetes, Pancreas

MBS639798-5x01mg 5x0.1mg
EUR 2915

Human Diabetes Skeletal Muscle Lysate Membrane Fraction

MBS8419497-01mg 0.1mg
EUR 1550

Human Diabetes Skeletal Muscle Lysate Membrane Fraction

MBS8419497-5x01mg 5x0.1mg
EUR 6780

Tissue, Total Protein, Human Disease, Diabetes, Whole Eye

MBS657222-1mg 1mg
EUR 1430

Tissue, Total Protein, Human Disease, Diabetes, Whole Eye

MBS657222-5x1mg 5x1mg
EUR 6225

Tissue, Section, Human Disease, Diabetes, Esophagus (Paraffin)

MBS640383-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Esophagus (Paraffin)

MBS640383-5x5Slides 5x5Slides
EUR 2145

Tissue, Total Protein, Human Disease, Diabetes, Bone Marrow

MBS657533-1mg 1mg
EUR 1430

Tissue, Total Protein, Human Disease, Diabetes, Bone Marrow

MBS657533-5x1mg 5x1mg
EUR 6225

Tissue, Section, Human Disease, Diabetes, Bone Marrow (Frozen)

MBS640718-5Slides 5Slides
EUR 930

Tissue, Section, Human Disease, Diabetes, Bone Marrow (Frozen)

MBS640718-5x5Slides 5x5Slides
EUR 3955

Tissue, Section, Human Disease, Diabetes, Bone Marrow (Paraffin)

MBS640435-5Slides 5Slides
EUR 510

Tissue, Section, Human Disease, Diabetes, Bone Marrow (Paraffin)

MBS640435-5x5Slides 5x5Slides
EUR 2145

Tissue, Total Protein, Human Disease, Diabetes, Skeletal Muscle

MBS657193-1mg 1mg
EUR 820
BackgroundDiabetes and consuming problems are steadily comorbid. This explicit comorbidity just isn’t solely usually poorly recognised, however is tough to deal with and has a excessive mortality.
MethodologyOn this article, we’ll briefly evaluation the connection between diabetes and consuming problems. We are going to evaluation the present NICE and different steering and studies regarding each diabetes and consuming problems in the UK. We are going to then describe the suggestions of the 2018 Welsh Authorities Consuming Dysfunction Service Evaluate and the 2021 the Scottish Authorities Consuming Dysfunction Service Evaluate concerning diabetes and consuming problems, which is able to result in service change.
ConclusionsWe conclude that this can be a comparatively underdeveloped however necessary space the place there must be additional service improvement and extra collaboration between diabetes and consuming dysfunction providers.
Introduction: Sodium-glucose co-transporter-2 (SGLT2) inhibitors reasonably scale back glucose ranges in type-2 diabetes mellitus (T2DM). Some instances of diabetic ketoacidosis (DKA) have been reported with SGLT2 inhibitors. Nevertheless, information on the long-term security of dapagliflozin in Saudi Arabia are missing. The current research aimed to watch the protection of dapagliflozin in sufferers with T2DM and consider the change in HbA1c through the remark interval in comparison with baseline.
Strategies: This was an area, potential, single-arm, non-interventional, regulatory post-marketing research. The research was performed in Saudi Arabia from Might 2017 to September 2019. Sufferers acquired both 5 or 10 mg dapagliflozin together with weight loss program and train modifications to deal with T2DM. The incidence of antagonistic occasions was noticed over the therapy period and for Three days after administering the final dose of dapagliflozin.
Outcomes: A complete of 527 sufferers have been recruited within the research, 524 of which have been eligible for the statistical evaluation. About 62% have been males. The median (IQR) age was 52.3 (14.8) years, whereas the median (IQR) physique mass index was 31.6 (7.7) kg/m2. The median (IQR) period because the sufferers have been first identified with T2DM was 8.78 (6.73) years. The commonest comorbidities have been hyperlipidemia (51.1%) and hypertension (41.1%). Virtually three-quarters of the research inhabitants (73.7%) acquired different antidiabetic drugs along with dapagliflozin.
Over a interval of 12 months, a complete of 106 antagonistic occasions have been skilled by 65 (12.33%) sufferers. Vulvovaginal pruritus (3.1%), dysuria (2.7%), polyuria (1.3%), urinary tract infections (1%), fatigue (0.8%), and hypoglycemia (0.8%) have been among the many reported antagonistic occasions. One case of DKA (0.2%) was reported. The imply (SD) HbA1c% degree considerably decreased from 8.6 (1.6) % at baseline to succeed in 7.2 (1.2) % after 12 months of therapy (p < 0.0001).
Conclusion: Dapagliflozin was discovered to be a effectively tolerated and efficient therapy possibility for T2DM sufferers in Saudi Arabia. Vulvovaginal pruritus and dysuria have been the commonest antagonistic occasions.
Goals: To judge the long-term penalties of espresso ingesting in sufferers with kind 2 diabetes.
Information synthesis: PubMed, Scopus, and Net of Sciences have been searched to November 2020 for potential cohort research evaluating the affiliation of espresso ingesting with danger of heart problems (CVD) and mortality in sufferers with kind 2 diabetes. Two reviewers extracted information and rated the certainty of proof utilizing GRADE method. Random-effects fashions have been used to estimate the hazard ratios (HRs) and 95% CIs. Dose-response associations have been modeled by a one-stage mixed-effects meta-analysis. Ten potential cohort research with 82,270 instances have been included. In comparison with these with no espresso consumption,
the HRs for consumption of Four cups/d have been 0.79 (95%CI: 0.72, 0.87; n = 10 research) for all-cause mortality, 0.60 (95%CI: 0.46, 0.79; n = 4) for CVD mortality, 0.68 (95%CI: 0.51, 0.91; n = 3) for coronary coronary heart illness (CHD) mortality, 0.72 (95%CI: 0.54, 0.98; n = 2) for CHD, and 0.77 (95%CI: 0.61, 0.98; n = 2) for whole CVD occasions. There was no vital affiliation for most cancers mortality and stroke. There was an inverse monotonic affiliation between espresso ingesting and all-cause and CVD mortality, and inverse linear affiliation for CHD and whole CVD occasions. The understanding of proof was graded average for all-cause mortality, and low or very low for different outcomes.
Conclusions: Consuming espresso could also be inversely related to the danger of mortality in sufferers with kind 2 diabetes. Nevertheless, extra analysis is required contemplating kind of espresso, sugar and cream added to espresso, and historical past of CVD to current extra assured outcomes.

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